Abstract\nBackground: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)ââ?¬â??\ninfected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU\nmay have a different healing rate in comparison to patients without IM. This study aimed to compare the\ndifference in GU healing between H. pyloriââ?¬â??infected patients with IM and those without IM.\nMethods: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period\nfrom March 2005 to January 2011. The inclusion criteria were: 1) endoscopic findings of GU and biopsy histological\nexamination plus rapid urease test indicating H. pylori infection; 2) gastric IM adjacent to a GU but with no atrophic\ngastritis changes; 3) patients receiving H. pylori eradication triple therapy and 8 weeks of maintenance therapy with\na proton pump inhibitor; and 4) patients receiving follow-up endoscopy within the 3rd and the 4th months after\ntreatment.\nResults: In total, 327 patients with GU and H. pylori infection (136 with IM and 191 without IM) were included.\nPatients with IM had a higher GU healing rate than those without IM (91.9% vs. 84.3%, P = 0.040). Multivariate\nlogistical regression analysis revealed that failure of H. pylori eradication (Odds = 4.013, 95% CI: 1.840ââ?¬â??8.951, P < 0.\n001) and gastric IM (Odds = 0.369, 95% CI: 0.168ââ?¬â??0.812, P = 0.013) were the predictors of non-healing GU following\ntreatment.\nConclusions: Patient with gastric IM change may have a higher GU healing rate than those without gastric IM.\nHowever, successful H. pylori eradication is a more important factor for GU healing than gastric IM.
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